Sermorelin Acetate
GHRH (1-29) analogue
A 29-amino-acid GHRH fragment that stimulates the pituitary to release growth hormone in natural pulses — a classic tool in GH-axis research.
Mechanism#
Represents the shortest fully active fragment of GHRH; it binds pituitary GHRH receptors to trigger physiological GH pulses, used to study GH/IGF-1 regulation.
Areas of research#
- GHRH-receptor research
- Physiological GH pulse studies
- GH/IGF-1 axis models
- Pituitary-function research
Sizes and pricing#
| Size | Price per vial | Availability |
|---|---|---|
| 2mg | £13 | Made to order — 1-2 weeks |
| 5mg | £28 | Made to order — 1-2 weeks |
| 10mg | £55 | In stock |
Buying more than one? Mix and match any peptide vials: 3 vials 8%, 5 vials 12%, 10 or more 15% off the peptides in your basket. You get whichever is better, the bulk or the volume discount, never both — applied automatically at checkout. How it works.
Technical specification#
| Molecular formula | C149H246N44O42S |
|---|---|
| Molecular weight | 3357.93 |
| CAS number | 86168-78-7 |
Batch documentation. Ask about the documentation for the batch we would ship before you order.
Check your certificate#
- Molecular weight 3357.9 (monoisotopic 3355.82). On a mass spectrum, expect charged ions near 1119.6, 840.0 and 672.2.
- Not CJC-1295 without DAC. Modified GRF(1-29) is 3367.9, only 10 heavier. A mass rounded to “about 3360” cannot separate the two.
- An amide, not an acid. The free-acid version of the same sequence is 3358.9, 1 heavier. The certificate should state the amide.
- Two by-products to look for. Oxidised sermorelin is 16 heavier, at 3373.9, and its triply charged ion lands near 1125.0, close to modified GRF’s. A peak near 3123.6 is GHRH(3-29), material that has lost its first two residues.
- Purity, with the method named, measured on that batch rather than quoted as a minimum.
Ask about the documentation for the batch we would ship before you order. How to check a certificate yourself: verifying a COA.
What’s in the vial#
| Fill | 2mg, 5mg or 10mg of peptide per vial |
|---|---|
| Appearance | Lyophilised powder |
| Salt form | Acetate. With five basic residues plus the free amino end, it can carry up to six counter-ions. A mass spectrum measures the peptide itself, so it should read 3357.9 whatever the salt. |
| Purity and content | Purity is the share of what was detected that is this peptide. Net peptide content, how much of the powder’s weight is peptide rather than salt and water, is a separate number. How much is in the vial. |
Handling at a glance#
| Solvent | Bacteriostatic or sterile water |
|---|---|
| Sealed vial | 2–8°C, dry and dark. Let it reach room temperature before opening. |
| Once in solution | 2–8°C. Avoid thawing and refreezing the same volume. |
| Worth knowing | A single methionine at position 27 oxidises, so it needs some extra care over air. Oxidised material reads 16 heavier on a certificate. |
Working out a concentration: the reconstitution calculator. Technique: the reconstitution guide and the storage guide.
What the research covers#
Sermorelin has more human data than most research peptides because it was once a licensed medicine in the United States. Serono’s Geref was approved by the FDA in a diagnostic form in 1990 and a second form in 1997; both were discontinued in 2008, and the FDA later determined that neither had been withdrawn for reasons of safety or effectiveness. Most of the human studies date from the late 1980s and 1990s and are small: a 1992 study comparing ten older men with nine young men, and a 1997 study of eleven men aged 64 to 76 with no placebo group, which measured a rise in night-time growth hormone release but no change in IGF-1 or body composition. It is not sold as a licensed medicine in the US today. Read the full guide, with sources: Sermorelin: Why 29 of GHRH's 44 Residues Are Enough.
Published literature#
- Guillemin R, Brazeau P, Böhlen P, et al. (1982). Science 218(4572):585–7. The first isolation and sequence of the 44-residue growth hormone-releasing factor, from a human pancreatic tumour. PubMed 6812220
- Ling N, Baird A, Wehrenberg WB, et al. (1984). Biochem Biophys Res Commun 123(2):854–61. Shortened versions of the 44-residue peptide, amide and free acid, tested on rat pituitary cells to find how much of the sequence is needed. PubMed 6435620
- Frohman LA, Downs TR, Williams TC, et al. (1986). J Clin Invest 78(4):906–13. Breakdown of natural GHRH in human plasma and in volunteers: removal of the first two residues by a plasma enzyme, and the activity of the shortened product. PubMed 3093533
- Corpas E, Harman SM, Piñeyro MA, et al. (1992). J Clin Endocrinol Metab 75(2):530–5. Ten healthy older men given GRF(1-29) twice a day for 14 days at two levels, compared with nine young men, measuring growth hormone and IGF-1. PubMed 1379256
- Prakash A, Goa KL. (1999). BioDrugs 12(2):139–57. Review of the evidence behind sermorelin's licensed uses as Geref. PubMed 18031173
- Knoop A, Thomas A, Fichant E, et al. (2016). Anal Bioanal Chem 408(12):3145–53. A validated anti-doping method for detecting several GHRH analogues in plasma, including sermorelin and its shortened form GHRH(3-29). PubMed 26879649
Listed so the work can be read at source. A paper on this list is evidence of what was studied, not of what any product does.
Questions#
What is sermorelin?
The first 29 residues of growth hormone-releasing hormone, GRF(1-29), made synthetically with nothing changed and amidated at the end. It is the parent of the later GHRH analogues, CJC-1295 among them.
What molecular weight should the certificate show?
3357.9 (monoisotopic 3355.82), usually seen as ions near 1119.6, 840.0 and 672.2. 3367.9 is CJC-1295 without DAC, 3358.9 is the free acid and 3373.9 is the oxidised form.
How should it be stored?
Sealed vial at 2-8°C, dry and dark. Once reconstituted with bacteriostatic or sterile water, keep it at 2-8°C and avoid thawing and refreezing the same volume. The methionine at position 27 oxidises, so take some extra care over air.
Is there a batch certificate?
Yes. The certificate for the current batch is available on request: email orders@pioneerpeptides.co.uk with the product and size.
Is it for human use?
No. It is supplied for laboratory research only, and we do not give guidance on human or animal use.
A batch-specific Certificate of Analysis is available on request. New to handling lyophilised material? See our reconstitution guide, storage guide and how to read a COA.