Snap-8

Acetyl octapeptide-3

An eight-residue peptide developed for topical cosmetic research, and an extension of the better-known acetyl hexapeptide sequence by two residues. It is studied for its interaction with the SNARE complex — the protein machinery that governs vesicle fusion.

Mechanism

The sequence is modelled on the N-terminal end of SNAP-25, one of the three proteins in the SNARE complex. Research interest is in whether a competing fragment interferes with SNARE assembly in in-vitro models. It is a topical cosmetic research peptide, not an injectable, and the literature on it is cosmetic-science literature rather than clinical.

Areas of research

• SNARE-complex assembly and vesicle-fusion models
• Topical formulation and peptide delivery through skin
• Structure–activity comparison with shorter acetyl hexapeptide analogues
• Peptide stability in cosmetic bases

Identity and specification

Two caps and a methionine — why the ends matter

Both termini are blocked: acetylated at the N-terminus, amidated at the C-terminus. That is not decoration. An unblocked peptide of this sequence has a free amine and a free acid, a different charge state and a different mass, and it is not the same compound — the acetyl group alone is 42 daltons. If a certificate for material sold as Snap-8 reports a mass near 1033 rather than 1075, the acetyl group is missing.

It also contains a methionine, which is the residue most prone to oxidation in storage. A +16 dalton satellite peak on a mass spectrum is the methionine sulfoxide, not a contaminant from somewhere else, and it is the reason this one is worth keeping cold and dark rather than merely cool.

Handling and storage

Supplied lyophilised. Store the sealed vial at −20°C, protected from light — see the note on methionine above. Reconstitute with bacteriostatic or sterile water run down the vial wall, never onto the powder; swirl, do not shake. Keep reconstituted material refrigerated and used promptly. See how to reconstitute research peptides and which solvent to use.

Sizes and pricing

Independently batch tested. A batch-specific certificate of analysis is available on request — ask for the certificate for the batch we would ship you before you order. Published certificates are in the COA library, each with the issuing laboratory’s verification key.

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